- Posted by jdavis on July 25, 2011
Other common name(s): antineoplastons, A10 (Atengenal, Cengenal), AS2-1 (Astugenal, Fengenal) Scientific/medical name(s): 3-phenylacetylamino-2,6-piperidinedione, phenylacetic acid, phenylacteylglutamine, phenylacetylisoglutamine
Antineoplaston therapy is a complementary/alternative cancer treatment that involves using a group of synthetic chemicals called antineoplastons to protect the body from disease. Antineoplastons are made up mostly of peptides and amino acids originally taken from human blood and urine.
Thousands of patients have been treated with antineoplastons, mostly at the same clinic, and clinical trials are underway there for many types of cancer. Published clinical trial results are available for a relatively small number of patients and the effectiveness of antineoplastons as a cancer therapy remains uncertain. Most cancer specialists believe there is not enough evidence to recommend use of antineoplastons, except perhaps in the context of clinical trials that will provide reliable information on the safety and effectiveness of this treatment.
How is it promoted for use?
Supporters have claimed antineoplastons are a part of something called the body’s “natural biochemical defense system.” This system is said to act independently from the body’s immune system and protect against diseases like cancer, which involve a breakdown in the chemistry of the body’s cells. Proponents claim antineoplaston therapy has been successful in treating many forms of cancer. They claim people with cancer don’t have enough naturally occurring antineoplastons, and that this therapy replenishes the body’s supply, allowing the biochemical defense system of the body to induce cancer cells to stop growing and become more like normal cells (cell differentiation).
What does it involve?
Antineoplastons are given by mouth or by injection into a vein. The treatment usually ranges over a period of 8 to 12 months. A year of treatment can cost approximately $30,000 to $60,000+, depending on the type of treatment, number of consultations, and the need for surgery to implant a catheter for drug delivery. Most insurance will not cover it. Initial treatments are given at a clinic in Houston (or at other US centers participating in studies to evaluate this treatment, as well as some centers in other countries) over 1 to 3 weeks. Further treatments may be given “at home,” but require visits to the clinic about every 2 months. Most of the patients who receive antineoplaston treatment also are treated with surgery, radiation, chemotherapy, or combinations of these standard treatments at other centers, and some receive chemotherapy prescribed by Dr. Burzynski.
Important: If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI’s Web site.
Burzynski Clinic, Houston, Texas
Stanislaw Burzynski, MD, PhD, Protocol Chair, phone 713-335-5697, email email@example.com
Dr. Burzynski is a controversial investigator. At one time the Food & Drug Administration shut him down. Many conventional oncologists are pre-disposed to be critical of his work. However, his protocol is now accepted for clinical trials by the National Cancer Institute. Early results in brain tumors are very promising. However, the regimen is very intense for the patient.